Article
Haplotype association and synergistic effect of human aldosterone synthase (CYP11B2) gene polymorphisms causing susceptibility to essential hypertension in Indian patients.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Jan 2000
Vamsi Uppuluri Mohana, Swapna Nagalingam, Padma Gunda, Vishnupriya Satti, Padma Tirunilai
Abstract excerpt
BACKGROUND: Aldosterone synthase (CYP11B2) is a key enzyme involved in the terminal steps of aldosterone biosynthesis. Genetic variability in CYP11B2 gene has been associated with heterogeneous aldosterone production, which can affect sodium homeostasis and thereby regulation of blood pressure. Hence, the present study was aimed to explore the single-locus variations, haplotype and epistasis patterns of CYP11B2...
Topics
- Aldosterone
- Alleles
- Blood Pressure
- Cytochrome P-450 CYP11B2
- DNA
- Essential Hypertension
- Female
- Genetic Predisposition to Disease
- Genotype
- Haplotypes