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Article

Association of CYP17A1 Genetic Polymorphisms and Susceptibility to Essential Hypertension in the Southwest Han Chinese Population.

Medical science monitor : international medical journal of experimental and clinical research - 24 May 2017

Li Qian, Gao Tangxin, Yuan Yuncang, Wu Yanrui, Huang Qionglin, Xie Fei, Ran Pengzhan, Sun Lijuan, Xiao Chunjie

Abstract excerpt

BACKGROUND The CYP17A1 gene encodes for cytochrome P450 enzyme CYP17A1, which is involved with the steroidogenic pathway including mineralocorticoids. The CYP17A1 polymorphisms might affect enzyme activity, then leading to a state of mineralocorticoid 11-deoxycorticosterone excess characterized by hypertension, suppressed plasma renin activity, and low aldosterone concentrations. The aim of this study was to...

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Identifiers

PMID: 28537227
DOI: 10.12659/msm.902109
PMCID: PMC5450854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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