Article
Association of the human CYP11B2 gene and essential hypertension in southwest Han Chinese population: a haplotype-based case-control study.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Jan 2011
Chen Bifeng, Nie Shengjie, Luo Shengjun, Zhang Wen, Xiao Chunjie
Abstract excerpt
Aldosterone synthase produces aldosterone, which regulates electrolytes and thereby blood pressure (BP). The aldosterone-synthase gene (CYP11B2) has been regarded as a candidate gene for essential hypertension. To address this issue, we carried out a haplotype-based, case-control study to explore the association between a human CYP11B2 gene and essential hypertension (EH) in the southwest Han population of China...
Topics
- Adult
- Aged
- Alleles
- Asian People
- Base Sequence
- Case-Control Studies
- China
- Cytochrome P-450 CYP11B2
- DNA Primers
- Female
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Hypertension