Article
Genetic heterogeneity in colorectal cancer associations between African and European americans.
Gastroenterology - 1 Nov 2010
Kupfer Sonia S, Anderson Jeffrey R, Hooker Stanley, Skol Andrew, Kittles Rick A, Keku Temitope O, Sandler Robert S, Ellis Nathan A
Abstract excerpt
BACKGROUND & AIMS: Genome-wide association studies of colorectal cancer (CRC) have identified risk variants in 10 genomic regions. None of these studies included African Americans, who have the highest incidence and mortality from CRC in the United States. For the 10 genomic regions, we performed an association study of Americans of African and European descent. METHODS: We genotyped 22 single nucleotide...
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