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Article

NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs.

FEBS letters - 8 Jul 1991

Sullivan J P, Connor J R, Tiffany C, Shearer B G, Burch R M

Abstract excerpt

We recently demonstrated that 2,6,diamino-N-[( 1-(oxotridecyl)-2-piperidinyl]methyl)-hexanamide (NPC 15437) is a selective inhibitor of PKC interacting at the regulatory domain of the enzyme. To further investigate the interaction of NPC 15437 with PKC we expressed a series of cDNAs encoding mutant PKC molecules in COS7 cells. NPC 15437 had no effect on the protein kinase activity of mutants lacking the...

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PMID: 2065775
DOI: 10.1016/0014-5793(91)80739-p

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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