Article
NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs.
FEBS letters - 8 Jul 1991
Sullivan J P, Connor J R, Tiffany C, Shearer B G, Burch R M
Abstract excerpt
We recently demonstrated that 2,6,diamino-N-[( 1-(oxotridecyl)-2-piperidinyl]methyl)-hexanamide (NPC 15437) is a selective inhibitor of PKC interacting at the regulatory domain of the enzyme. To further investigate the interaction of NPC 15437 with PKC we expressed a series of cDNAs encoding muta...
Topics
- 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
- Alkaloids
- Amino Acid Sequence
- Animals
- Binding Sites
- Cell Line
- DNA Mutational Analysis
- Isoquinolines
- Macromolecular Substances
- Molecular Sequence Data
- Mutation
- Phorbol 12,13-Dibutyrate
- Piperazines
- Piperidines
- Protein Conformation
- Protein Kinase C
- Staurosporine
- Tetradecanoylphorbol Acetate