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Article

Protein kinase C contains two phorbol ester binding domains.

The Journal of biological chemistry - 25 Sept 1991

Burns D J, Bell R M

Abstract excerpt

A series of deletion and truncation mutants of protein kinase C (PKC) were expressed in the baculovirus-insect cell expression system in order to elucidate the ability of various domains of the enzyme to bind phorbol dibutyrate (PDBu). A PKC truncation mutant consisting of only the catalytic domain of the enzyme did not bind [3H]PDBu, whereas a PKC truncation mutant consisting of the regulatory domain (containing...

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PMID: 1917958

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