Differential protein kinase C ligand regulation detected in vivo by a phenotypic yeast assay.

doi:10.1002/mc.2940120308

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Article

Differential protein kinase C ligand regulation detected in vivo by a phenotypic yeast assay.

Molecular carcinogenesis - 1 Mar 1995

Shieh H L, Hansen H, Zhu J, Riedel H

Abstract excerpt

The molecular dissection of protein kinase C (PKC) action has been based in part on time-consuming functional assays such as the mouse skin model for testing the tumor promoter activity of phorbol esters and related PKC activators. To help overcome the limitations imposed by the complexity of such assays, we developed the yeast Saccharomyces cerevisiae as an alternative, rapid, and simple experimental system....

Topics

Animals
Base Sequence
Carcinogens
Catalysis
Cattle
Cell Division
Cloning, Molecular
Diterpenes
Drug Evaluation, Preclinical
Indoles
Lactams
Ligands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Phenotype

Protein Kinase C

Regulatory Sequences, Nucleic Acid

Saccharomyces cerevisiae

Source

Open in PubMed

Identifiers

PMID: 7893369
DOI: 10.1002/mc.2940120308

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7893369-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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