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Article

Ca2+ modulation of cis-unsaturated fatty acid-induced mutant protein kinase C activity: indication of inhibitory Ca2+-binding site in protein kinase C-alpha.

The Biochemical journal - 1 Jul 1998

Eshete F, Chung H, Gannon-Murakami L, Murakami K

Abstract excerpt

The C2 domain in protein kinase C (PKC) is homologous to equivalent domains in a number of important cytoplasmic proteins. Except for its implied function in Ca2+ and phospholipid binding, the precise role of this domain is not well understood. We examined the role of the C2 domain of PKC-alpha u...

Topics

Animals
Binding Sites
COS Cells
Calcium
Diglycerides
Enzyme Activation
Enzyme Induction
Fatty Acids, Unsaturated
Isoenzymes
Mutation
Phospholipids
Protein Kinase C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombinant Proteins

Sequence Deletion

Stereoisomerism

Source

Open in PubMed Open full text

Identifiers

PMID: 9639582
DOI: 10.1042/bj3330215
PMCID: PMC1219575

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9639582-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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