Article
Ligand regulation of bovine protein kinase C alpha response via either cysteine-rich repeat of conserved region C1.
Journal of biochemistry - 1 May 1994
Zhu J, Hansen H, Su L, Shieh H L, Riedel H
Abstract excerpt
Based on the finding by others that the conserved region C1 of conventional protein kinase C isoforms carries two independent, cysteine-rich phorbol ester binding sites, we have mapped the structural elements of the C1 region for their role in the phorbol ester- and phospholipid regulation of PKC alpha responses. We have prepared two amino terminal truncation mutants of bovine PKC alpha, ND91 lacking the first...
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