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Article

Curcumin Inhibits Protein Kinase Cα Activity by Binding to Its C1 Domain.

Biochemistry - 15 Nov 2016

Pany Satyabrata, You Youngki, Das Joydip

Abstract excerpt

Curcumin is a polyphenolic nutraceutical that acts on multiple biological targets, including protein kinase C (PKC). PKC is a family of serine/threonine kinases central to intracellular signal transduction. We have recently shown that curcumin selectively inhibits PKCα, but not PKCε, in CHO-K1 cells [Pany, S. (2016) Biochemistry 55, 2135-2143]. To understand which domain(s) of PKCα is responsible for curcumin...

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Identifiers

PMID: 27776404
DOI: 10.1021/acs.biochem.6b00932
PMCID: PMC5657492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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