Article
Inhibition of protein kinase C catalytic activity by additional regions within the human protein kinase Calpha-regulatory domain lying outside of the pseudosubstrate sequence.
The Biochemical journal - 15 Jul 2003
Kirwan Angie F, Bibby Ashley C, Mvilongo Thierry, Riedel Heimo, Burke Thomas, Millis Sherri Z, Parissenti Amadeo M
Abstract excerpt
The N-terminal pseudosubstrate site within the protein kinase Calpha (PKCalpha)-regulatory domain has long been regarded as the major determinant for autoinhibition of catalytic domain activity. Previously, we observed that the PKC-inhibitory capacity of the human PKCalpha-regulatory domain was only reduced partially on removal of the pseudosubstrate sequence [Parissenti, Kirwan, Kim, Colantonio and Schimmer...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.