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Article

The Role of Regulatory Domains in Maintaining Autoinhibition in the Multidomain Kinase PKCα.

The Journal of biological chemistry - 17 Feb 2017

Sommese Ruth F, Ritt Michael, Swanson Carter J, Sivaramakrishnan Sivaraj

Abstract excerpt

Resolving the conformational dynamics of large multidomain proteins has proven to be a significant challenge. Here we use a variety of techniques to dissect the roles of individual protein kinase Cα (PKCα) regulatory domains in maintaining catalytic autoinhibition. We find that whereas the pseudosubstrate domain is necessary for autoinhibition it is not sufficient. Instead, each regulatory domain (C1a, C1b, and...

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Identifiers

PMID: 28049730
DOI: 10.1074/jbc.M116.768457
PMCID: PMC5314182

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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