Article
Heterologous basic domain substitutions in the HIV-1 Tat protein reveal an arginine-rich motif required for transactivation.
The EMBO journal - 1 Aug 1991
Subramanian T, Govindarajan R, Chinnadurai G
Abstract excerpt
The Tat protein coded by HIV-1 is a unique eukaryotic transactivator. It activates gene expression from the viral LTR by its interaction with a nascent RNA element (TAR) located at the 5' end of all HIV-1 transcripts. Tat appears to bind to its target RNA structure in a highly sequence-specific m...
Topics
- Amino Acid Sequence
- Arginine
- Cell Line
- Chimera
- Fluorescent Antibody Technique
- Gene Products, rex
- Gene Products, tat
- Genes, Viral
- HIV-1
- HeLa Cells
- Human T-lymphotropic virus 1
- Humans
- Molecular Sequence Data
- Mutation
- Transcriptional Activation
- tat Gene Products, Human Immunodeficiency Virus