Article
The 57th amino acid conveys the differential subcellular localization of human immunodeficiency virus-1 Tat derived from subtype B and C.
Virus genes - 1 Apr 2016
Zhao Xuechao, Qian Lingyu, Qi Di, Zhou Deyu, Shen Wenyuan, Liu Yu, Liu Chang, Kong Xiaohong
Abstract excerpt
The multifunctional transactivator Tat protein is an essentially regulatory protein for HIV-1 replication and it plays a role in pathogenesis of HIV-1 infection. At present, numerous experimental studies about HIV-1 Tat focus on subtype B, very few has been under study of subtype C-Tat. In view of the amino acid variation of the clade-specific Tat proteins, we hypothesized that the amino acid difference...
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