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Article

Genetic modulation of TLR8 response following bacterial phagocytosis.

Human mutation - 1 Sept 2010

Gantier Michael P, Irving Aaron T, Kaparakis-Liaskos Maria, Xu Dakang, Evans Vanessa A, Cameron Paul U, Bourne James A, Ferrero Richard L, John Matthias, Behlke Mark A, Williams Bryan R G

Abstract excerpt

Human Toll-like receptors (TLRs) TLR7, TLR8, and TLR9 are important immune sensors of foreign nucleic acids encountered by phagocytes. Although there is growing evidence implicating TLR7 and TLR9 in the detection of intracellular pathogenic bacteria, characterization of such a role for TLR8 is currently lacking. A recent genetic study has correlated the presence of a TLR8 single nucleotide polymorphism (SNP)...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20652908
DOI: 10.1002/humu.21321

Genes

TLR8
TLR7
TLR9

Variants

rs3764880

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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