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Article

The polymorphism P315L of human toll-like receptor 1 impairs innate immune sensing of microbial cell wall components.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2007

Omueti Katherine O, Mazur Daniel J, Thompson Katherine S, Lyle Elizabeth A, Tapping Richard I

Abstract excerpt

As a pattern recognition receptor, TLR1 mediates innate immune responses to a variety of microbial cell wall components including bacterial lipoproteins. We have previously shown that the central region of the extracellular domain of human TLR1, comprising leucine-rich repeat (LRR) motifs 9-12, is required for the sensing of bacterial lipopeptides. In this study, we have investigated three nonsynonymous single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17475868
DOI: 10.4049/jimmunol.178.10.6387

Genes

TLR1

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