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Article

Toll-like receptor 2 (P631H) mutant impairs membrane internalization and is a dominant negative allele.

Scandinavian journal of immunology - 1 May 2010

Etokebe G E, Skjeldal F, Nilsen N, Rodionov D, Knezevic J, Bulat-Kardum L, Espevik T, Bakke O, Dembic Z

Abstract excerpt

We have sequenced 416 Toll-like receptor-2 (TLR2) alleles in 208 subjects in a tuberculosis case-control study in Croatian Caucasian population. We found ten single nucleotide polymorphisms (SNP) among which three were novel (S97S, T138I and L266F). The genotype containing TLR2-P631H SNP was significantly overrepresented in patients with tuberculosis when compared to contact controls, suggesting a small yet...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20500688
DOI: 10.1111/j.1365-3083.2010.02379.x

Genes

TLR2
TLR1
TLR6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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