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Article

The BRCT domain of PARP-1 is required for immunoglobulin gene conversion.

PLoS biology - 20 Jul 2010

Paddock Marcia N, Buelow Ben D, Takeda Shunichi, Scharenberg Andrew M

Abstract excerpt

Genetic variation at immunoglobulin (Ig) gene variable regions in B-cells is created through a multi-step process involving deamination of cytosine bases by activation-induced cytidine deaminase (AID) and their subsequent mutagenic repair. To protect the genome from dangerous, potentially oncogen...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20652015
DOI: 10.1371/journal.pbio.1000428
PMCID: PMC2907289

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20652015-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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The BRCT domain of PARP-1 is required for immunoglobulin gene conversion.PMID 20652015Read ↗

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Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombinationSemantic proximity Read ↗

Targeting of AID-mediated sequence diversification to immunoglobulin genes.Semantic proximity Read ↗

DNA Lesions and Repair in Immunoglobulin Class Switch Recombination and Somatic HypermutationSemantic proximity Read ↗

Immunoglobulin class-switch recombination deficienciesSemantic proximity Read ↗

Large deletions in immunoglobulin genes are associated with a sustained absence of DNA Polymerase η.Semantic proximity Read ↗

AIDing antibody diversity by error-prone mismatch repair.Semantic proximity Read ↗

SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation.Semantic proximity Read ↗

MRE11/RAD50 Cleaves DNA in the AID/UNG-Dependent Pathway of Immunoglobulin Gene DiversificationSemantic proximity Read ↗

Isolation of region-specific factors assembled on the Immunoglobulin heavy chain locus during antibody class switch recombinationSemantic proximity Read ↗

Controlling somatic hypermutation in immunoglobulin variable and switch regions.Semantic proximity Read ↗

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