Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of TNF, MBL, and VDR polymorphisms with leprosy phenotypes.

Human immunology - 1 Oct 2010

Sapkota Bishwa R, Macdonald Murdo, Berrington William R, Misch E Ann, Ranjit Chaman, Siddiqui M Ruby, Kaplan Gilla, Hawn Thomas R

Abstract excerpt

Although genetic variants in tumor necrosis factor (TNF), mannose binding lectin (MBL), and the vitamin D receptor (VDR) have been associated with leprosy clinical outcomes, these findings have not been extensively validated. We used a case-control study design with 933 patients in Nepal, which included 240 patients with type I reversal reaction (RR), and 124 patients with erythema nodosum leprosum (ENL)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Mutational Analysis
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leprosy

Share to Mannose-Binding Lectin

Share to Promoter Regions, Genetic

Share to Receptors, Calcitriol

Share to Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 20650301
DOI: 10.1016/j.humimm.2010.07.001
PMCID: PMC2941523

Genes

TNF
VDR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of TNF, MBL, and VDR polymorphisms with leprosy phenotypes.PMID 20650301Read ↗

The -308 bp TNF gene polymorphism influences tumor necrosis factor expression in leprosy patients in Bahia State, Brazil.Semantic proximity Read ↗

Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction.Semantic proximity Read ↗

Impact of TNF -308 G>A (rs1800629) gene polymorphism in modulation of leprosy risk: a reappraise meta-analysis of 14 case-control studies.Semantic proximity Read ↗

VDR polymorphism, gene expression and vitamin D levels in leprosy patients from North Indian populationSemantic proximity Read ↗

Association of Taq I, Fok I and Apa I polymorphisms in Vitamin D Receptor (VDR) gene with leprosy.Semantic proximity Read ↗

HLA-DRB1*04 and DRB1*10 are associated with resistance and susceptibility, respectively, in Brazilian and Vietnamese leprosy patients.Semantic proximity Read ↗

Polymorphisms in Toll-like receptor 4 (TLR4) are associated with protection against leprosy.Semantic proximity Read ↗

Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions.Semantic proximity Read ↗

Association of polymorphisms in the TNFA, TNFRSF1A and TNFRSF1B genes with lepromatous leprosy in Western Mexican patients.Semantic proximity Read ↗

TNF -308G>A single nucleotide polymorphism is associated with leprosy among Brazilians: a genetic epidemiology assessment, meta-analysis, and functional study.Semantic proximity Read ↗

Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy.Semantic proximity Read ↗

Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.