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Article

Polymorphisms in Toll-like receptor 4 (TLR4) are associated with protection against leprosy.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Sept 2009

Bochud P-Y, Sinsimer D, Aderem A, Siddiqui M R, Saunderson P, Britton S, Abraham I, Tadesse Argaw A, Janer M, Hawn T R, Kaplan G

Abstract excerpt

Accumulating evidence suggests that polymorphisms in Toll-like receptors (TLRs) influence the pathogenesis of mycobacterial infections, including leprosy, a disease whose manifestations depend on host immune responses. Polymorphisms in TLR2 are associated with an increased risk of reversal reaction, but not susceptibility to leprosy itself. We examined whether polymorphisms in TLR4 are associated with...

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Source

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Identifiers

PMID: 19430824
DOI: 10.1007/s10096-009-0746-0
PMCID: PMC3016895

Genes

TLR4
TLR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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