Article
Human NPY promoter variation rs16147:T>C as a moderator of prefrontal NPY gene expression and negative affect.
Human mutation - 1 Aug 2010
Sommer Wolfgang H, Lidström Jessica, Sun Hui, Passer Derek, Eskay Robert, Parker Stephen C J, Witt Stephanie H, Zimmermann Ulrich S, Nieratschker Vanessa, Rietschel Marcella, Margulies Elliott H, Palkovits Miklós, Laucht Manfred, Heilig Markus
Abstract excerpt
Studies in humans and animals suggest a role for NPY in the mediation of behavioral stress responses. Here, we examined whether the NPY promoter variant rs16147:T>C is functional for expression of NPY in a brain region relevant for behavioral control, anxiety and depression, the anterior cingulate cortex. In silico analysis of DNA structural profile changes produced by rs16147 variation suggests allelic...
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