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Article

Allele-specific programming of Npy and epigenetic effects of physical activity in a genetic model of depression.

Translational psychiatry - 7 May 2013

Melas P A, Lennartsson A, Vakifahmetoglu-Norberg H, Wei Y, Åberg E, Werme M, Rogdaki M, Mannervik M, Wegener G, Brené S, Mathé A A, Lavebratt C

Abstract excerpt

Neuropeptide Y (NPY) has been implicated in depression, emotional processing and stress response. Part of this evidence originates from human single-nucleotide polymorphism (SNP) studies. In the present study, we report that a SNP in the rat Npy promoter (C/T; rs105431668) affects in vitro transcription and DNA-protein interactions. Genotyping studies showed that the C-allele of rs105431668 is present in a...

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Identifiers

PMID: 23652932
DOI: 10.1038/tp.2013.31
PMCID: PMC3669918

Genes

NPY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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