Article
NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults.
Depression and anxiety - 1 Mar 2010
Amstadter Ananda B, Koenen Karestan C, Ruggiero Kenneth J, Acierno Ron, Galea Sandro, Kilpatrick Dean G, Gelernter Joel
Abstract excerpt
BACKGROUND: Neuropeptide Y (NPY) has been found to be anxiolytic in animals and humans. A recent study found NPY expression to be inversely correlated with trait anxiety. We examined whether rs16147, a functional single nucleotide polymorphism in the promoter region of NPY, moderated the relationship between hurricane exposure and risk for generalized anxiety disorder (GAD) in an epidemiologic sample of adults...
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