Article
Association between neuropeptide Y receptor Y2 promoter variant rs6857715 and major depressive disorder.
Psychiatric genetics - 1 Feb 2017
Treutlein Jens, Strohmaier Jana, Frank Josef, Witt Stephanie H, Rietschel Liz, Forstner Andreas J, Lang Maren, Degenhardt Franziska, Dukal Helene, Herms Stefan, Streit Fabian, Hoffmann Per, Cichon Sven, Nöthen Markus M, Rietschel Marcella
Abstract excerpt
Stress increases the risk for major depressive disorder (MDD), overeating, and alcohol dependence (AD). The neuropeptide Y system is one of the best-known modulators of the stress response, and some of its effects are mediated through the neuropeptide Y receptor Y2 (NPY2R). The functional NPY2R variant rs6857715 (C-599T) has been implicated in both obesity and AD, but with opposing alleles. The present study...
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