Genetic variation in the neuropeptide Y gene promoter is associated with increased risk of tobacco smoking.

doi:10.1159/000338276

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Article

Genetic variation in the neuropeptide Y gene promoter is associated with increased risk of tobacco smoking.

European addiction research - 1 Jan 2012

Mutschler Jochen, Abbruzzese Elvira, von der Goltz Christoph, Dinter Christina, Mobascher Arian, Thiele Holger, Diaz-Lacava Amalia, Dahmen Norbert, Gallinat Jürgen, Majic Tomislav, Petrovsky Nadine, Kornhuber Johannes, Thuerauf Norbert, Gründer Gerhard, Brinkmeyer Jürgen, Wienker Thomas, Wagner Michael, Winterer Georg, Kiefer Falk

Abstract excerpt

BACKGROUND: Neuropeptide Y (NPY) is a strong candidate gene regarding the pathophysiology of tobacco dependence. It has been associated with various addictive and psychiatric disorders, and closely interacts with the brain reward system. The aim of the present study was to test for association between a functional genetic variant in the NP-Y promoter gene (SNP rs16147) and tobacco smoking. METHODS: In a...

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PMID: 22584873
DOI: 10.1159/000338276

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