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Article

Effects of mutant huntingtin on mGluR5-mediated dual signaling pathways: implications for therapeutic interventions.

Cellular and molecular neurobiology - 1 Oct 2010

Huang Shan-Shan, He Jun, Zhao Dong-Ming, Xu Xiao-Yuan, Tan Hui-Ping, Li He

Abstract excerpt

Glutamate excitotoxicity is thought to play an important role in Huntington's disease (HD), which is caused by a polyglutamine expansion in the HD protein huntingtin (htt). Overactivation of group I metabotropic glutamate receptors (mGluRs), which include mGluR1 as well as mGluR5 and are coupled via phospholipase C to the inositol phosphate pathway, is found to be involved in mutant htt-mediated neurotoxicity....

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Identifiers

PMID: 20644995
DOI: 10.1007/s10571-010-9543-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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