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Article

Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin.

The Journal of biological chemistry - 14 Oct 2005

Anborgh Pieter H, Godin Christina, Pampillo Macarena, Dhami Gurpreet K, Dale Lianne B, Cregan Sean P, Truant Ray, Ferguson Stephen S G

Abstract excerpt

Huntington disease is caused by a polyglutamine expansion in the huntingtin protein (Htt) and is associated with excitotoxic death of striatal neurons. Group I metabotropic glutamate receptors (mGluRs) that are coupled to inositol 1,4,5-triphosphate formation and the release of intracellular Ca(2+) stores play an important role in regulating neuronal function. We show here that mGluRs interact with the...

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Source

Identifiers

PMID: 16091361
DOI: 10.1074/jbc.M504508200

Genes

GRK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin.PMID 16091361Read ↗

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Posttranslational Modifications, Localization, and Protein Interactions of Optineurin, the Product of a Glaucoma GeneSemantic proximity Read ↗

Optineurin and Its Mutants: Molecules Associated with Some Forms of GlaucomaSemantic proximity Read ↗

Functional analysis of optineurin and some of its disease-associated mutants.Semantic proximity Read ↗

Defects in autophagy caused by glaucoma-associated mutations in optineurin.Semantic proximity Read ↗

Optineurin: A Coordinator of Membrane-Associated Cargo Trafficking and Autophagy.Semantic proximity Read ↗

A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity.Semantic proximity Read ↗

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