Article
CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice.
Molecular and cellular neurosciences - 1 Sept 2008
Apostol Barbara L, Simmons Danielle A, Zuccato Chiara, Illes Katalin, Pallos Judit, Casale Malcolm, Conforti Paola, Ramos Catarina, Roarke Margaret, Kathuria Satish, Cattaneo Elena, Marsh J Lawrence, Thompson Leslie Michels
Abstract excerpt
Huntington's disease (HD) is a devastating neurodegenerative disorder caused by an expanded polyglutamine repeat within the protein Huntingtin (Htt). We previously reported that mutant Htt expression activates the ERK1/2 and JNK pathways [Apostol, B.L., Illes, K., Pallos, J., Bodai, L., Wu, J., Strand, A., Schweitzer, E.S., Olson, J.M., Kazantsev, A., Marsh, J.L., Thompson, L.M., 2006. Mutant huntingtin alters...
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