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Article

Activation of Elk-1 participates as a neuroprotective compensatory mechanism in models of Huntington's disease.

Journal of neurochemistry - 1 May 2012

Anglada-Huguet Marta, Giralt Albert, Perez-Navarro Esther, Alberch Jordi, Xifró Xavier

Abstract excerpt

The transcription factor Elk-1 has been revealed as neuroprotective against toxic stimuli. In this study, we explored the neuroprotective capacity of Elk-1 in Huntington's disease. To this aim, we used two exon-1 mutant huntingtin (mhtt) mouse models (R6/1 and R6/2), and a full-length mhtt striatal cell model (STHdh(Q111/Q111) ). Analysis of Elk-1 and pElk-1(Ser383) in the striatum of R6 mice revealed increased...

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PMID: 22372926
DOI: 10.1111/j.1471-4159.2012.07711.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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