Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

mGluR5 antagonism increases autophagy and prevents disease progression in the zQ175 mouse model of Huntington’s disease

19 Dec 2017

Abstract excerpt

mice. The findings suggest that mGluR5 antagonism may activate autophagy through convergent mechanisms to promote the clearance of mutant huntingtin aggregates and might be therapeutic in HD patients.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Genetic Neurodegenerative Diseases
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29259100
DOI: 10.1126/scisignal.aan6387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

mGluR5 antagonism increases autophagy and prevents disease progression in the zQ175 mouse model of Huntington’s diseasePMID 29259100Read ↗

Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington’s pathology in zQ175 miceSemantic proximity Read ↗

Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer’s disease mouse modelsSemantic proximity Read ↗

mGluR5 ablation leads to age-related synaptic plasticity impairments and does not improve Huntington's disease phenotype.Semantic proximity Read ↗

Small molecule modulation of p75NTR engages the autophagy-lysosomal pathway and reduces huntingtin aggregates in cellular and mouse models of Huntington's diseaseSemantic proximity Read ↗

mGluR5 Contribution to Neuropathology in Alzheimer Mice Is Disease Stage-DependentSemantic proximity Read ↗

Huntington's disease and Group I metabotropic glutamate receptors.Semantic proximity Read ↗

Enhanced Hippocampal Spare Capacity in Q175DN Mice Despite Elevated mHTT AggregationSemantic proximity Read ↗

Glutamine Synthetase-1 induces autophagy-lysosomal degradation of huntingtin aggregates and ameliorates animal motility in a <i>Drosophila</i> model for Huntington’s diseaseSemantic proximity Read ↗

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.Semantic proximity Read ↗

Metabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington's disease.Semantic proximity Read ↗

Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levelsSemantic proximity Read ↗

Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.