Article
Polygenic nature of spontaneous diabetes in the rat. Permissive MHC haplotype and presence of the lymphopenic trait of the BB rat are not sufficient to produce susceptibility.
Diabetes - 1 Dec 1992
Colle E, Fuks A, Poussier P, Edouard P, Guttmann R D
Abstract excerpt
We describe the phenotypic characteristics of animals in the fifth backcross-intercross generation of a breeding program in which the RT1 u haplotype and the phenotypic trait responsible for the T-lymphopenia of BB rats have been transferred to the ACI background. In this generation of animals, 2...
Topics
- Animals
- Antibodies, Monoclonal
- CD4 Antigens
- CD8 Antigens
- Crosses, Genetic
- DNA
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- Female
- Flow Cytometry
- Genetic Predisposition to Disease
- Haplotypes
- Lymphocyte Activation
- Lymphocytes
- Major Histocompatibility Complex
- Male
- Phenotype
- Rats