Article

Glycoprotein VI is Critical for the Detection and Progression of Abdominal Aortic Aneurysms

2023-07-05

Abstract excerpt

<h4>ABSTRACT</h4> A common feature in patients with abdominal aortic aneurysms (AAA) is the formation of a nonocclusive intraluminal thrombus (ILT) in regions of aortic dilation. Platelets are known to maintain hemostasis and propagate thrombosis through several redundant activation mechanisms, yet the role of platelet activation in the pathogenesis of AAA associated ILT is still poorly understood. Thus, we sough...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 78e9ecde-b4a2-5dd5-bb00-67e785ce9ba8
DOI: 10.1101/2023.07.02.547361

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Glycoprotein VI is Critical for the Detection and Progression of Abdominal Aortic AneurysmsDOI 10.1101/2023.07.02.547361Read

Collagen receptor GPVI-mediated platelet activation and pro-coagulant activity aggravates inflammation and aortic wall remodelling in abdominal aortic aneurysmSemantic proximity Read

Platelets are Protective in Early Abdominal Aortic Aneurysm FormationSemantic proximity Read

Crosstalk of platelets with macrophages and fibroblasts aggravates inflammation, aortic wall stiffening and osteopontin release in abdominal aortic aneurysmSemantic proximity Read

Comprehensive bioinformatics analysis revealed potential key genes and pathways underlying abdominal aortic aneurysmSemantic proximity Read

Identification and Experimental Validation of NETosis-Mediated Abdominal Aortic Aneurysm Gene Signature Using Multi-omics, Machine Learning, and Mendelian RandomizationSemantic proximity Read

Altered MicroRNA Signatures in Circulating Extracellular Vesicles Reflect Aortic Dilation in Takayasu ArteritisSemantic proximity Read

Single-Cell RNA Sequencing Deconstructs the Distribution of Immune Cells Within Abdominal Aortic Aneurysms in MiceSemantic proximity Read

Proteomic analysis of intraluminal thrombus highlights complement activation in human abdominal aortic aneurysms.Semantic proximity Read

Human genetic evidence to inform clinical development of interleukin-6 signaling inhibition for abdominal aortic aneurysmSemantic proximity Read

Pathogenesis of Abdominal Aortic Aneurysms: MicroRNAs, Proteases, Genetic AssociationsSemantic proximity Read

Human Genetic Evidence to Inform Clinical Development of IL-6 Signaling Inhibition for Abdominal Aortic Aneurysm.Semantic proximity Read

Platelet-derived small extracellular vesicles (PDsEVs) sequencing unveils MEF2B as potential target in atherosclerosis-related diseasesSemantic proximity Read