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Article

Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Mar 2017

Zhang Zhong-Hao, Wu Qiu-Yan, Zheng Rui, Chen Chen, Chen Yao, Liu Qiong, Hoffmann Peter R, Ni Jia-Zuan, Song Guo-Li

Abstract excerpt

Tau pathology was recently identified as a key driver of disease progression and an attractive therapeutic target in Alzheimer's disease (AD). Selenomethionine (Se-Met), a major bioactive form of selenium (Se) in organisms with significant antioxidant capacity, reduced the levels of total tau and hyperphosphorylated tau and ameliorated cognitive deficits in younger triple transgenic AD (3xTg-AD) mice. Whether...

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Identifiers

PMID: 28137967
DOI: 10.1523/JNEUROSCI.3229-16.2017
PMCID: PMC6596838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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