Article
Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models.
Neurobiology of disease - 1 Mar 2012
Jones Nigel C, Nguyen Thanh, Corcoran Niall M, Velakoulis Dennis, Chen Tracy, Grundy Robert, O'Brien Terence J, Hovens Christopher M
Abstract excerpt
Tau hyperphosphorylation has been implicated in the pathogenesis of a variety of forms of human epilepsy. Here we investigated whether treatment with sodium selenate, a drug which reduces pathological hyperphosphorylated tau by enhancement of PP2A activity, would inhibit seizures in rodent models. In vitro, sodium selenate reduced tau phosphorylation in human neuroblastoma cells and reversed the increase in tau...
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