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Article

Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Rueli Rachel H L H, Torres Daniel J, Dewing Andrea S T, Kiyohara Arlene C, Barayuga Stephanie M, Bellinger Miyoko T, Uyehara-Lock Jane H, White Lon R, Moreira Paula I, Berry Marla J, Perry George, Bellinger Frederick P

Abstract excerpt

Previous studies demonstrated that selenium in the form of sodium selenate reduces neurofibrillary tangle formation in Alzheimer's disease models. Hyperphosphorylation of tau, which leads to formation of neurofibrillary tangles in Alzheimer's disease, is increased by endoplasmic reticulum (ER) stress. Selenoprotein S (SelS) is part of an ER membrane complex that removes misfolded proteins from the ER as a means...

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Identifiers

PMID: 27802219
DOI: 10.3233/JAD-151208
PMCID: PMC5893862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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