Article

Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy

2022-05-19

Abstract excerpt

There are no pharmacological disease-modifying treatments that can mitigate the seizures and comorbidities associated with established chronic temporal lobe epilepsy (TLE). This study evaluated the effect of sodium selenate in the post-status epilepticus (SE) rat model of chronic drug resistant TLE. Wistar rats underwent kainic acid-induced SE or sham. Ten-weeks post-SE, rats were randomly assigned to receive eith...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 466ee2fc-a0fe-52c6-b7e3-41c6136f3626
DOI: 10.1101/2022.05.17.492323

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsyDOI 10.1101/2022.05.17.492323Read

Personalised Therapeutic and Dietary Interventions as an Alternative Non-Invasive Management of Temporal Lobe EpilepsySemantic proximity Read

Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models.Semantic proximity Read

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models.Semantic proximity Read

Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy.Semantic proximity Read

Proteomic Profiling of the Hippocampus of Rats Subjected to the Pilocarpine Model of EpilepsySemantic proximity Read

High concordance between hippocampal transcriptome of the intraamygdala kainic acid model and human temporal lobe epilepsySemantic proximity Read

High concordance between hippocampal transcriptome of the mouse intra‐amygdala kainic acid model and human temporal lobe epilepsySemantic proximity Read

Epilepsy research: a window onto function to and dysfunction of the human brain.Semantic proximity Read

Combined transcriptomics and proteomics forecast analysis for potential biomarker in the acute phase of temporal lobe epilepsySemantic proximity Read

Pharmacogenomic Analysis of Medial Temporal Lobe Epilepsy with Hippocampal Sclerosis in Humans and Animal ModelsSemantic proximity Read

Lowered Paraoxonase 1 Activities May Explain the Comorbidities Between Temporal Lobe Epilepsy or Mesial Temporal Sclerosis and Comorbid Depression, Anxiety and PsychosisSemantic proximity Read

Tau Related Pathways as a Connecting Link between Epilepsy and Alzheimer’s DiseaseSemantic proximity Read