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Article

A unique methylation pattern co-segregates with neural tube defect statuses in Han Chinese pedigrees.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Dec 2017

Zhang Ruiping, Cao Lirong, Wang Yizheng, Fang Yulian, Zhao Linsheng, Li Weidong, Shi Ou-Yan, Cai Chun-Quan

Abstract excerpt

Neural tube defects (NTDs) are a complex trait associated with gene-environment interactions. Folic acid deficiency and planar cell polarity gene mutations account for some NTD cases; however, the etiology of NTDs is still little understood. In this study, in three Han Chinese NTD pedigrees (two with multiple affected children), with no information on folic acid deficiency or supplement, we examined genome-wide...

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Source

Identifiers

PMID: 28980068
DOI: 10.1007/s10072-017-3132-1

Genes

CDH23
HDAC4
HOXB7
SMAD6
SOX18
ZEB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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