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Relation between hypomethylation of long interspersed nucleotide elements and risk of neural tube defects

18 Feb 2010

Abstract excerpt

BACKGROUND: Impaired one-carbon metabolism is thought to be associated with the risk of neural tube defects (NTDs); however, the role of methylation in NTDs remains unclear. Long interspersed nucleotide element-1 (LINE-1) constitutes 17-25% of the human genome. LINE-1 hypomethylation correlates with global DNA methylation levels in cancerous cells, but limited information is available on LINE-1 methylation in...

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PMID: 20164316
DOI: 10.3945/ajcn.2009.28858

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