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Article

DNA methylation analysis of Homeobox genes implicates HOXB7 hypomethylation as risk factor for neural tube defects.

Epigenetics - 1 Jan 2015

Rochtus Anne, Izzi Benedetta, Vangeel Elise, Louwette Sophie, Wittevrongel Christine, Lambrechts Diether, Moreau Yves, Winand Raf, Verpoorten Carla, Jansen Katrien, Van Geet Chris, Freson Kathleen

Abstract excerpt

Neural tube defects (NTDs) are common birth defects of complex etiology. Though family- and population-based studies have confirmed a genetic component, the responsible genes for NTDs are still largely unknown. Based on the hypothesis that folic acid prevents NTDs by stimulating methylation reactions, epigenetic factors, such as DNA methylation, are predicted to be involved in NTDs. Homeobox (HOX) genes play a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25565354
DOI: 10.1080/15592294.2014.998531
PMCID: PMC4622610

Genes

HOXB7
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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