Article
Caffeine, selected metabolic gene variants, and risk for neural tube defects.
Birth defects research. Part A, Clinical and molecular teratology - 1 Jul 2010
Schmidt Rebecca J, Romitti Paul A, Burns Trudy L, Murray Jeffrey C, Browne Marilyn L, Druschel Charlotte M, Olney Richard S
Abstract excerpt
BACKGROUND: Investigations of maternal caffeine intake and neural tube defects (NTDs) have not considered genetic influences. Caffeine metabolism gene effects were examined in the National Birth Defects Prevention Study. METHODS: Average daily caffeine was summed from self-reported coffee, tea, soda, and chocolate intake for mothers of 768 NTD cases, and 4143 controls delivered from 1997 to 2002. A subset of 306...
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