Article
Stillbirth and slow metabolizers of caffeine: comparison by genotypes.
International journal of epidemiology - 1 Aug 2006
Bech Bodil Hammer, Autrup Herman, Nohr Ellen Aagaard, Henriksen Tine Brink, Olsen Jørn
Abstract excerpt
BACKGROUND: Cytochrome P4501A2 (CYP1A2) and N-acetyltransferase 2 (NAT2) are key enzymes in the metabolism of caffeine. The polymorphism of these genes facilitates the detection of fast and slow metabolizers, and if caffeine is causally related to stillbirth, we expect slow metabolizers to have a higher risk of stillbirth at any given intake of caffeine. Gluthatione S-transferase alpha1 (GSTA1) may also be active...
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