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Article

Role of the activation peptide in the mechanism of protein C activation.

Scientific reports - 6 Jul 2020

Stojanovski Bosko M, Pelc Leslie A, Di Cera Enrico

Abstract excerpt

Protein C is a natural anticoagulant activated by thrombin in a reaction accelerated by the cofactor thrombomodulin. The zymogen to protease conversion of protein C involves removal of a short activation peptide that, relative to the analogous sequence present in other vitamin K-dependent proteins, contains a disproportionately high number of acidic residues. Through a combination of bioinformatic, mutagenesis...

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Identifiers

PMID: 32632109
DOI: 10.1038/s41598-020-68078-z
PMCID: PMC7338465

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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