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Article

Genetic deficiency of plasma lipoprotein-associated phospholipase A2 (PLA2G7 V297F null mutation) and risk of Alzheimer's disease in Japan.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Koshy Beena, Miyashita Akinori, St Jean Pamela, Stirnadel Heide, Kaise Toshihiko, Rubio Justin P, Mooser Vincent, Kuwano Ryozo, Irizarry Michael C

Abstract excerpt

High plasma lipoprotein phospholipase A2 activity (Lp-PLA2) is reported to be a risk factor for dementia. A loss of function polymorphism in the Lp-PLA2 gene - PLA2G7 V279F - is found almost exclusively in Asians. In 1,952 subjects with late-onset AD and 2,079 non-demented controls recruited from Japan, the PLA2G7 null allele was not associated with risk or age at onset of AD: logistic regression OR 0.98 (95% CI...

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Identifiers

PMID: 20634581
DOI: 10.3233/JAD-2010-100513

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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