Article
Comprehensive evaluation of genetic and environmental factors influencing the plasma lipoprotein-associated phospholipase A2 activity in a Japanese population.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 May 2007
Zhang Shao-Yan, Shibata Hiroshi, Karino Kenji, Wang Bin-You, Kobayashi Shotai, Masuda Junichi, Nabika Toru
Abstract excerpt
The lipoprotein-associated phospholipase A2 (Lp-PLA2) metabolizes oxidized phospholipids, generating lysophosphatidylcholine. The activity of the enzyme is known to be influenced largely by a single-nucleotide polymorphism, G994T, in the Lp-PLA2 gene. Interestingly, this polymorphism is much more...
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