Article
Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population.
Journal of Alzheimer's disease : JAD - 1 Jan 2014
Miyashita Akinori, Wen Yanan, Kitamura Nobutaka, Matsubara Etsuro, Kawarabayashi Takeshi, Shoji Mikio, Tomita Naoki, Furukawa Katsutoshi, Arai Hiroyuki, Asada Takashi, Harigaya Yasuo, Ikeda Masaki, Amari Masakuni, Hanyu Haruo, Higuchi Susumu, Nishizawa Masatoyo, Suga Masaichi, Kawase Yasuhiro, Akatsu Hiroyasu, Imagawa Masaki, Hamaguchi Tsuyoshi, Yamada Masahito, Morihara Takashi, Takeda Masatoshi, Takao Takeo, Nakata Kenji, Sasaki Ken, Watanabe Ken, Nakashima Kenji, Urakami Katsuya, Ooya Terumi, Takahashi Mitsuo, Yuzuriha Takefumi, Serikawa Kayoko, Yoshimoto Seishi, Nakagawa Ryuji, Saito Yuko, Hatsuta Hiroyuki, Murayama Shigeo, Kakita Akiyoshi, Takahashi Hitoshi, Yamaguchi Haruyasu, Akazawa Kohei, Kanazawa Ichiro, Ihara Yasuo, Ikeuchi Takeshi, Kuwano Ryozo
Abstract excerpt
Rare non-synonymous variants of TREM2 have recently been shown to be associated with Alzheimer's disease (AD) in Caucasians. We here conducted a replication study using a well-characterized Japanese sample set, comprising 2,190 late-onset AD (LOAD) cases and 2,498 controls. We genotyped 10 non-synonymous variants (Q33X, Y38C, R47H, T66M, N68K, D87N, T96K, R98W, H157Y, and L211P) of TREM2 reported by Guerreiro et...
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