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Article

Comprehensive variant analysis of phospholipase A2 superfamily genes in large Chinese Parkinson' s disease cohorts.

Mechanisms of ageing and development - 1 Jun 2024

Liu Jiabin, Wang Yige, Zhao Yuwen, Pan Hongxu, Liu Zhenhua, Xu Qian, Lu Shen, Jiang Hong, Wang Junling, Sun Qiying, Tan Jieqiong, Yan Xinxiang, Li Jinchen, Tang Beisha, Guo Jifeng

Abstract excerpt

To clarify the genetic role of phospholipase A2 (PLA2) genes in Parkinson's disease (PD), we performed a genetic association study in large Chinese population cohorts using next-generation sequencing. In this study, we analyzed both rare and common variants of 38 phospholipase A2 genes in two large cohorts. We detected 1558 and 1115 rare variants in these two cohorts, respectively. In both cohorts, we observed...

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Source

Identifiers

PMID: 38750970
DOI: 10.1016/j.mad.2024.111940

Genes

ABHD12
PLA2G12A
PLA2G12B
PLA2G15
PLA2G2D
PLA2G4F
PLA2G7
PLAAT5
PNPLA1
PNPLA3
PNPLA7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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