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Article

p62/Sequestosome-1 Associates with and Sustains the Expression of Retroviral Restriction Factor TRIM5α

1 Apr 2010

Abstract excerpt

TRIM5 proteins mediate a potent block to the cross-species transmission of retroviruses, the most well known being the TRIM5alpha protein from rhesus macaques, which potently inhibits human immunodeficiency virus type 1 (HIV-1) infection. This restriction occurs at an early stage in the replication cycle and is mediated by the binding of TRIM5 proteins to determinants present in the retroviral capsid. TRIM5alpha,...

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PMID: 20357094
DOI: 10.1128/jvi.02412-09

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