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Article

Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection.

Proceedings of the National Academy of Sciences of the United States of America - 9 May 2006

Si Zhihai, Vandegraaff Nick, O'huigin Colm, Song Byeongwoon, Yuan Wen, Xu Chen, Perron Michel, Li Xing, Marasco Wayne A, Engelman Alan, Dean Michael, Sodroski Joseph

Abstract excerpt

Primate tripartite motif 5alpha (TRIM5alpha) proteins mediate innate intracellular resistance to retroviruses. In humans, TRIM5 is located in a paralogous cluster that includes TRIM6, TRIM34, and TRIM22. Although TRIM6 and TRIM34 orthologs are found in other mammals, TRIM5 has to date been identi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16648259
DOI: 10.1073/pnas.0600771103
PMCID: PMC1464360

Genes

TRIM5
TRIM34
TRIM6
TRIM22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16648259-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection.PMID 16648259Read ↗

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All three variable regions of the TRIM5alpha B30.2 domain can contribute to the specificity of retrovirus restriction.Semantic proximity Read ↗

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