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Article

The contribution of RING and B-box 2 domains to retroviral restriction mediated by monkey TRIM5alpha.

The Journal of biological chemistry - 22 Jul 2005

Javanbakht Hassan, Diaz-Griffero Felipe, Stremlau Matthew, Si Zhihai, Sodroski Joseph

Abstract excerpt

TRIM5alpha is a cytoplasmic protein that mediates a post-entry block to infection by some retroviruses. TRIM5alpha contains a tripartite motif (TRIM), which includes RING, B-box 2, and coiled-coil domains, and a C-terminal B30.2 (SPRY) domain. We investigated the contribution of the RING and B-box 2 domains to the antiretroviral activity of rhesus monkey TRIM5alpha (TRIM5alpharh), which potently restricts...

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Identifiers

PMID: 15897199
DOI: 10.1074/jbc.M502145200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The contribution of RING and B-box 2 domains to retroviral restriction mediated by monkey TRIM5alpha.PMID 15897199Read ↗

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