Article
Family-based association analysis of 42 hereditary prostate cancer families identifies the Apolipoprotein L3 region on chromosome 22q12 as a risk locus.
Human molecular genetics - 1 Oct 2010
Johanneson Bo, McDonnell Shannon K, Karyadi Danielle M, Quignon Pascale, McIntosh Laura, Riska Shaun M, FitzGerald Liesel M, Johnson Gregory, Deutsch Kerry, Williams Gabrielle, Tillmans Lori S, Stanford Janet L, Schaid Daniel J, Thibodeau Stephen N, Ostrander Elaine A
Abstract excerpt
Multiple genome-wide scans for hereditary prostate cancer (HPC) have identified susceptibility loci on nearly every chromosome. However, few results have been replicated with statistical significance. One exception is chromosome 22q, for which five independent linkage studies yielded strong evidence for a susceptibility locus in HPC families. Previously, we refined this region to a 2.53 Mb interval, using...
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